Use the Metro 2033 No Intro Fix.
%LOCALAPPDATA%\4A Games\Metro 2033\user.cfg
Some users have encountered issues such as not being able to set their native resolution; the game resetting their chosen resolution to a lower one; or the game's maximum available resolution being lower than their monitor's native resolution. Such cases may be caused by the presence of multiple monitors attached to the computer, or attempting to play the game on an attached TV where larger resolutions may not be available. Possible solutions include unplugging any extra monitors or setting the multi-monitor display mode in Windows to "Computer Only".
C:\Program Files (x86)\NVIDIA Corporation\PhysX\Common
If you're running Lucid Virtu MVP, you will need to disable the control panel entirely, not just uncheck Metro 2033 from the application list.
This may be due to crouching while your companion is being dragged off the cart. Just don't do that.
Install Metro Mouse Fix.