During the level "Chase Venom", Spider-Man must chase venom to a skyscraper, where-in the game plays an in-game cut scene of the two chasing each other through the skyscraper. There is a bug that causes Spider-Man to follow an improper path while chasing venom out of the building near the end, causing Spider-Man to become to far apart from Venom, causing a game-over.
The game has trouble detecting specific audio drivers properly. For example, using Bluetooth headphones causes the audio become heavily distorted. The audio will mute for certain music and sounds in-game, but will blare the music on the menu, and any dialogue from characters in-game to the point of distortion. The loud audio also gets louder overtime, despite being turned down to the lowest setting in the audio menu.
See Frame rate capping to set a 30 FPS cap.