This is mostly commenting on this edit and my edit after that.
So basically game was designed to run at solid 60 FPS, on consoles game would then slow down when too much stuff was happening instead of dropping frames. The way developer ensured this on PC was forcing vsync on, so with regular 60Hz monitor game would run that 60 FPS. This just means that vsync does indeed work, but they just though that every monitor is 60Hz so that they could use it as capping method. They left it at that, meaning that with over 60Hz monitors there will be speedup issues and some sort of cap has to be set in place, even if sonic is about the speed.
Easiest way to do this will be setting refresh rate to 60Hz, but this has some nasty negative impacts (which other high refresh rate owners may know about) which include visual things like flickering effect which gets really annoying as well as colors getting bit washed out (which is why I hate the games forcing refresh rate change), then not to mention that setting monitor to 60Hz every time before launching the game. It's still solution, yes, but far from perfect one and thus I feel like completely wiping note about frame rate capping and telling user to change monitors refresh rate instead isn't good. I made section about frame rate capping into frame rate article, but forgot to update it here. (If you meant games launcher option to set the game 60Hz, it simply doesn't work and always uses monitors refresh rate anyway.)
Now for Nvidia Inspector, when I tested the frame rate issues I was using mainly Dxtorys capping, but Nvidia Inspector worked absolutely fine and it's basically best solution for frame rate capping as it's automatic and game specific. Now I tested it again, I was using this profile as an test and it worked just fine, so I would like to see some more information that somehow Inspector would be the reason for the game to crash - or forced FXAA or other AA method.
However what I did notice was that any sort of in-game overlay would make the game flip over and crash on launch. Also that PC has hard time Alt+Tab ↹ as well as Alt+f4 not working at all. Rebooting the game after initial launch or setting hook delay made it launch just fine though.