Resident Evil 4
Resident Evil 4 was released for Windows in 2005. Beware that this is a somewhat neglected port of a great game. Capcom definitely phoned it in on this one, but that does not detract from the fact that this is a great game which is widely considered a classic and possibly the best entry in the Resident Evil series.
Tweaks
There are very limited options in the game, but it has surprisingly good controller support that simply works without any configurations. There are a few tweakable parameters in the SetupTool.ini file which resides in the install directory.
SetupTool.ini
Resolution
Under the [SCREEN] section of the config file, there are SizeX and SizeY values, which correspond to resolutionWidth and resolutionHeight. For example if you want the game to run at 1920x1080, set them to:
sizeX=1920 sizeY=1080
Controls
There is a slew of gamepad and keyboard configuration settings in here which you can set.
Mods
There are many mods and texture enhancement mods available for download to improve the visuals of this aging gem.
Resident Evil 4 PC Texture Pack 2.0
This is a sizable effort of love with a couple gigs of higher resolution textures that improve the entire game. It can be downloaded from The Pirate Bay.
Enhanced Environment
Cerberus84 from ModDB has made texture pack which improves upon the default textures included with the game and can be downloaded from modDB.
Enb Series
The prolific Boris Vorontsov has a lighting/graphical patch available which greatly improves how the game looks, though it may decrease performance in some cases. You can get it form his site.