Run Steam, then set affinity (on steam.exe) & check cores from 0-7, run the game & it should be fine. I've had plenty of problems with this game & tried almost everything, and this was the only fix that actually worked for me. Hope this helps.
Talk:NBA 2K21
+ and the same works for a few other games I've had the same issues with (such as Mortal Kombat Komplete Edition, Injustice: Gods, Capcom Arcade Stadium,...)
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