Topic on Talk:Ultimate Spider-Man
The game does not work on modern Windows due to the SafeDisc DRM functionality being removed from Windows 10 and up due to security concerns. Either use a cracked .exe removing the DRM or follow the directions listed here to reenable the DRM functionality in Windows (which is considered unsafe currently due to the vulnerability it poses): https://www.pcgamingwiki.com/wiki/Digital_rights_management_(DRM)#SafeDisc