The file naming convention appears to be this:
In-game general video settings.
In-game advanced video settings (1/2).
In-game advanced video settings (2/2).
In-game key map settings (1/3).
In-game key map settings (2/3).
In-game key map settings (3/3).
The gamepad layout for the game.
Using a 4k monitor or super resolution techniques like Nvidia DSR results in very small HUD elements. No solution is known for this.
HKEY_CURRENT_USER\Software\Eidos\Deus Ex: HRDC
There are multiple solutions that people have reported work:
HKEY_CURRENT_USER\Software\Eidos\Deus Ex: HRDC\Graphics
An alternative work-around for some users, without disabling their graphics card, is to add "-nosound" to the Steam Launch Options. Some additional testing is needed to verify if this works for the majority of users.
Despite the wording of the setting being added, this does not disable sound for the game.
Change the values of these lines so they look like this