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Topic on Talk:Fallout: New Vegas

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There's also the 4GB enabler (ability to use 4GB of mem) and NVSE, which is required by a lot of mods.

4GB enabler http://newvegas.nexusmods.com/downloads/file.php?id=35262

NVSE http://nvse.silverlock.org/

If you load a huge number of mods, the 4GB enabler may be necessary to keep things humming.